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FLASH GENE

Symbol

FBXL4

contributors: mct - updated : 26-09-2012

HGNC name	F-box and leucine-rich repeat protein 4
HGNC id	13601

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	74.25 kb     9 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_012160 9 - 2777 NP_036292 - 621 - 2013 2399319

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive liver         Endocrine pancreas         Respiratory lung         Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N-terminal mitochondrial targeting sequence (MTS) essential to target FBXL4 to mitochondria
	F-box 40AA domain
	a canonical FBXL functional domains
	a AMN1 domain
	a C terminal nine leucine-rich repeats (LRR), ribonuclease inhibitor type

HOMOLOGY

Homologene

FAMILY

F-box protein family

CATEGORY

adaptor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,interspace
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus
text	F-box protein that colocalizes with mitochondria

basic FUNCTION	phosphorylation dependent uniquination
	substrate recognition subunit of SCF ubiquitin protein ligase complex
	mitochondrial protein with a possible role in maintaining mtDNA integrity and stability
	role for FBXL4 in controlling bioenergetic homeostasis and mtDNA maintenance

CELLULAR PROCESS

protein, ubiquitin dependent proteolysis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

one of the four subunits of the E3 ubiquitin protein ligase complex :(SCF) with SKP1, CUL1, RBX1, F-box protein bringing ubiquitin conjugating enzymes to substrates recruited by F-box

INTERACTION

DNA

RNA

small molecule

protein	various target proteins
	FBXL4 interacted with KDM4A and regulated protein turnover

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

MTDPS13

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS