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FLASH GENE

Symbol

CUL1

contributors: mct/pgu - updated : 20-02-2018

HGNC name	cullin 1
HGNC id	2551

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   significantly associated with high-grade tumours and poor prognosis tumoral     --over   in renal cell carcinoma (RCC) tumoral     --over   in melanoma, enhancing melanoma cell proliferation by promoting G1-S phase transition tumoral     --over   positively associated with lymph node metastasis and tumor diameter tumoral     --over   significantly increased in human glioma, and it may be involved in proliferation, migration and invasion of glioma cells

Susceptibility

may affect the susceptibility of rheumatoid arthritis (RA) via altering lymphocyte signal transduction

Variant & Polymorphism other	possible role of CUL1 variation(s) in RA and its response to methotrexate

Candidate gene
Marker	its expression may therefore be crucial for the prediction of disease outcome in breast cancer patients
	CUL1 may be an important prognosis marker for human hepatocellular carcinoma (HCC)
	may serve as promising prognostic markers in colorectal cancer (CRC) patients
Therapy target
	System Type Disorder Pubmed cancer urinary   CUL1 may constitute a potential therapeutic target in enal cell carcinoma (RCC)

ANIMAL & CELL MODELS

	dysregulation of cyclin E and early embryonic lethality in CUL1-/-
	cul1-/- sequestrate and inactivate Skp1 leading to genetic instability and neoplastic transformation