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FLASH GENE
Symbol HNRNPM contributors: npt/mct - updated : 31-08-2018
HGNC name heterogeneous nuclear ribonucleoprotein M
HGNC id 5046
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three RNP-CS domains
  • A central region spanning amino acids 248–344 required for interaction with CDC5L/PLRG1
    • conjugated RiboP
    HOMOLOGY
    Homologene
    FAMILY
  • HNRP family
    • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • involved in splicing
  • N-acetyl-glucosamine-specific receptor
  • is able to associate with early spliceosomes and to influence splicing patterns of specific pre-mRNAs
  • abundant nuclear protein that binds to pre-mRNA and is a component of the spliceosome complex
  • involvement in the spliceosome machinery through its interaction with the CDC5L/PLRG1 spliceosomal subcomplex
  • can influence both constitutive and alternative splicing
  • participation of HNRNPM in an expanding network of protein-protein interactions suggesting its important functioning in the coordination of transcriptional and post-transcriptional events
  • promotes breast cancer metastasis by activating the switch of alternative splicing that occurs during epithelial-mesenchymal transition (EMT)
  • ESRP1 and HNRNPM are splicing regulators that promote an epithelial splicing program and a mesenchymal splicing program, respectively
    • CELLULAR PROCESS nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of heterogeneous nuclear RNA ribonucleoprotein complex
    • INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • carcinoembryonic antigen binds to Kupffer cells and macrophages to a membrane-anchored homolog of HNRPM (CEAR)
  • HNRNPM interacts with SFPQ and NONO and co-localizes within defined nuclear structures
  • interaction between HNRPM and the spliceosome proteins cell division cycle 5-like (CDC5L) and pleiotropic regulator 1 (PLRG1)
  • NOVA1 and HNRNPM are DRD2 pre-mRNA-binding proteins with antagonistic role in the alternative splicing of DRD2 pre-mRNA
  • nuclear IGF2BP3-HNRNPM complex is important for the efficient synthesis of CCND1, CCND3 and CCNG1 and for the proliferation of human cancer cells
  • HNRNPM promotes exon 7 inclusion of SMN1 and SMN2 pre-mRNA through targeting an enhancer on exon 7 through recruiting U2AF2
  • CD44 is a key downstream target of HNRNPM
  • cooperative function of HNRNPM and NONO as regulators of internal ribosome entry site (IRES)-dependent translation, indicating the involvement of a promoter-dependent mechanism
  • complex modes of interaction between HNRNPM and ESRP1 in regulation of splicing in disease-relevant contexts
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS