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FLASH GENE
Symbol HNRNPM contributors: npt/mct - updated : 31-08-2018
HGNC name heterogeneous nuclear ribonucleoprotein M
HGNC id 5046
RNA
TRANSCRIPTS type messenger
text with four isoforms M1, M2, M3, M4 (64,68kDa) (Datar)
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
16 - 2553 77.4 730 - 1996 8692693
17 - 2436 73.5 691 - 1996 8692693
- - - 68 - - Datar (1993)
also called M1
- - - 68 - - Datar (1993)
also called M2
14 - 2540 68 595 - Datar (1993)
also called M3
- - 2450 77 729 - 1996 8692693
also called M4
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
 pharynx   highly
Endocrinethyroid   highly
Gustatory (taste)tongue    
Lymphoid/Immunethymus    
Reproductivefemale systemuterus  highly
 male systemtestis   
Visualeye    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three RNP-CS domains
  • A central region spanning amino acids 248–344 required for interaction with CDC5L/PLRG1
    • conjugated RiboP
    HOMOLOGY
    Homologene
    FAMILY
  • HNRP family
    • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • involved in splicing
  • N-acetyl-glucosamine-specific receptor
  • is able to associate with early spliceosomes and to influence splicing patterns of specific pre-mRNAs
  • abundant nuclear protein that binds to pre-mRNA and is a component of the spliceosome complex
  • involvement in the spliceosome machinery through its interaction with the CDC5L/PLRG1 spliceosomal subcomplex
  • can influence both constitutive and alternative splicing
  • participation of HNRNPM in an expanding network of protein-protein interactions suggesting its important functioning in the coordination of transcriptional and post-transcriptional events
  • promotes breast cancer metastasis by activating the switch of alternative splicing that occurs during epithelial-mesenchymal transition (EMT)
  • ESRP1 and HNRNPM are splicing regulators that promote an epithelial splicing program and a mesenchymal splicing program, respectively
    • CELLULAR PROCESS nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of heterogeneous nuclear RNA ribonucleoprotein complex
    • INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • carcinoembryonic antigen binds to Kupffer cells and macrophages to a membrane-anchored homolog of HNRPM (CEAR)
  • HNRNPM interacts with SFPQ and NONO and co-localizes within defined nuclear structures
  • interaction between HNRPM and the spliceosome proteins cell division cycle 5-like (CDC5L) and pleiotropic regulator 1 (PLRG1)
  • NOVA1 and HNRNPM are DRD2 pre-mRNA-binding proteins with antagonistic role in the alternative splicing of DRD2 pre-mRNA
  • nuclear IGF2BP3-HNRNPM complex is important for the efficient synthesis of CCND1, CCND3 and CCNG1 and for the proliferation of human cancer cells
  • HNRNPM promotes exon 7 inclusion of SMN1 and SMN2 pre-mRNA through targeting an enhancer on exon 7 through recruiting U2AF2
  • CD44 is a key downstream target of HNRNPM
  • cooperative function of HNRNPM and NONO as regulators of internal ribosome entry site (IRES)-dependent translation, indicating the involvement of a promoter-dependent mechanism
  • complex modes of interaction between HNRNPM and ESRP1 in regulation of splicing in disease-relevant contexts
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS