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FLASH GENE
Symbol HPSE2 contributors: mct/npt - updated : 24-01-2009
HGNC name heparanase 2
HGNC id 18374
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a domain showing sequence homology to the glycosyl hydrolase motif in the heparanase (HPSE)
    • HOMOLOGY
    Homologene
    FAMILY
  • heparanase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    basic FUNCTION
  • may be playing a role in extracellular matrix remodeling and in increasing heparin-binding growth factor release during embryo implantation (D'Souza 2008)
  • may be important for the synergic action of muscles implicated in facial expression and urine voiding (Pang 2010)
  • required for normal lower-urinary-tract innervation and/or neural function
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • constituents of the extracellular matrix and basement membrane
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) UFS
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS