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FLASH GENE

Symbol

PDZK1IP1

contributors: mct/npt - updated : 13-11-2009

HGNC name	PDZK1 interacting protein 1
HGNC id	16887

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon     Urinary kidney tubule convoluted tubule proximal tubule highly

cells

System Cell Pubmed Species Stage Rna symbol Urinary epithelial cell

cell lineage
cell lines	overexpressed in many carcinoma cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies	ortholog to rattus Map17
	ortholog to murine Map17

Homologene

FAMILY

CATEGORY

protooncogene

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,Golgi
text	nonglycosylated membrane protein that localizes to the plasma membrane and the Golgi apparatus (Guijarro 2007)

basic FUNCTION	playing a potential role in early malignant transformation
	activates AKT through ROS (reactive oxygen species) and this is determinant to confer resistance to Myc-induced apoptosis in the absence of serum (Guijarro 2007)
	non-glycosylated membrane-associated protein that has been shown to be over-expressed in carcinomas (Guijarro 2007)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS