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FLASH GENE
Symbol TNPO1 contributors: mct - updated : 13-10-2021
HGNC name transportin 1
HGNC id 6401
PROTEIN
PHYSICAL PROPERTIES acid
STRUCTURE
motifs/domains
  • height HEAT repeats
  • one importin N-terminal domain
    • conjugated PhosphoP
    mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Tnpo1 (99.7pc)
    homolog to rattus Tnpo1 (99.4pc)
    Homologene
    FAMILY
  • karyopherin family
  • importin beta family
    • CATEGORY receptor nuclear , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus,nucleolus
    text minimally detected in cytoplasmic processing bodies under normal cell conditions, but largely translocated to stress granules in stressed cells
    basic FUNCTION
  • mediating nuclear import of ribonucleoprotein A1
  • may participate in cellular function of P-bodies (Chang 2009)
  • playing a role in trafficking of ZFP36 between the cytoplasmic granules and whereby modulates the stability of ARE-containing mRNA
  • functions in nuclear protein import as nuclear transport receptor
  • serving as receptor for nuclear localization signals (NLS) in cargo substrates
  • is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin
  • involved in nuclear import of M9-containing proteins
  • mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5
  • plays likely a major role in nuclear localization of FUS
  • TNPO1 is a pivotal contributor to the gynecologic cancer progression
  • TNPO1/TNPO2 activity directly impacts ciliogenesis, mitotic spindle assembly, and nuclear envelope and pore assembly
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text nucleocytoplasmic transport, nuclear import of ribosomal proteins
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimer composed of an alpha subunit which recognizes the nuclear localization signal and a beta subunit which docks the complex at nucleoporins
  • ternary complex comprising TNPO1, RAB8 and the ciliary targeting signal directs proteins to ciliary membranes
  • redox-dependent PPARG/TNPO1 complex formation enhances PPARG nuclear localization and signaling
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NUP98 involved in the termination of KPNB2 mediated nuclear import
  • binding to HNRPA1, HNRPA2 and mediating nuclear import
  • binding specifically to the GTP-bound form of RAN
  • binding HNRPDL, RPL23A, RPS7, RPL5, SRP19
  • interacting with H2A, H2B, H3 and H4 histones
  • binding to HIV-1 Rev
  • associating with ZFP36 and its AU-rich element-containing mRNA substrates
  • interacting with CCR2, followed by CCR2 receptor internalization
  • HNRNPA1 preferentially binds TNPO1, TNPO2
  • interacting with CD44
  • FUS bind the import-karyopherin, karyopherinbeta2 (TNPO1) in a RAN-sensitive manner
  • TNPO1 mediates YBX1 nuclear translocation
  • O-GlcNAcylation, regulates likely HNRNPA1 translocation and interaction with TNPO1, possibly affecting its function
  • interaction of TNPO1 and TNPO3 with the nonclassical NLSs may regulate the formation of membraneless organelles and subcellular localization of numerous protein
  • mechanistically, TNPO1 is selectively responsible for nuclear import of ARID1B, which is a synthetic lethal target in ARID1A-inactivating mutation cancers
    • cell & other
    REGULATION
    inhibited by NUP98
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS