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FLASH GENE

Symbol

TNPO1

contributors: mct - updated : 13-10-2021

HGNC name	transportin 1
HGNC id	6401

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	97.74 kb     25 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_153188 25 - 8546 NP_694858 101.3 890 - 2020 32161167 NM_002270 25 - 8559 NP_002261 101.3 898 - 2020 32161167 NM_001364292 25 - 8691 NP_001351221 - 890 - 2020 32161167 NM_001364293 25 - 8406 NP_001351222 - 890 - 2020 32161167 NM_001364295 24 - 8339 NP_001351224 - 848 - 2020 32161167 NM_001364294 24 - 8414 NP_001351223 - 858 - 2020 32161167 NM_001364296 6 - 1813 NP_001351225 - 197 - 2020 32161167

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain forebrain cerebral cortex   moderately Homo sapiens   brain limbic system hippocampus   highly Homo sapiens   brain hindbrain cerebellum   highly Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES		acid
STRUCTURE

motifs/domains	height HEAT repeats
	one importin N-terminal domain

conjugated

PhosphoP

mono polymer

heteromer , dimer

HOMOLOGY

interspecies	homolog to murine Tnpo1 (99.7pc)
	homolog to rattus Tnpo1 (99.4pc)

Homologene

FAMILY	karyopherin family
	importin beta family

CATEGORY

receptor nuclear , transport carrier

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,cytosolic
	intracellular,cytoplasm,cytoskeleton,microtubule
	intracellular,nucleus,nucleolus
text	minimally detected in cytoplasmic processing bodies under normal cell conditions, but largely translocated to stress granules in stressed cells

basic FUNCTION	mediating nuclear import of ribonucleoprotein A1
	may participate in cellular function of P-bodies (Chang 2009)
	playing a role in trafficking of ZFP36 between the cytoplasmic granules and whereby modulates the stability of ARE-containing mRNA
	functions in nuclear protein import as nuclear transport receptor
	serving as receptor for nuclear localization signals (NLS) in cargo substrates
	is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin
	involved in nuclear import of M9-containing proteins
	mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5
	plays likely a major role in nuclear localization of FUS
	TNPO1 is a pivotal contributor to the gynecologic cancer progression
	TNPO1/TNPO2 activity directly impacts ciliogenesis, mitotic spindle assembly, and nuclear envelope and pore assembly

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

cellular trafficking transport

text	nucleocytoplasmic transport, nuclear import of ribosomal proteins

PATHWAY

metabolism

signaling

a component	heterodimer composed of an alpha subunit which recognizes the nuclear localization signal and a beta subunit which docks the complex at nucleoporins
	ternary complex comprising TNPO1, RAB8 and the ciliary targeting signal directs proteins to ciliary membranes
	redox-dependent PPARG/TNPO1 complex formation enhances PPARG nuclear localization and signaling

INTERACTION

DNA

RNA

small molecule

protein	NUP98 involved in the termination of KPNB2 mediated nuclear import
	binding to HNRPA1, HNRPA2 and mediating nuclear import
	binding specifically to the GTP-bound form of RAN
	binding HNRPDL, RPL23A, RPS7, RPL5, SRP19
	interacting with H2A, H2B, H3 and H4 histones
	binding to HIV-1 Rev
	associating with ZFP36 and its AU-rich element-containing mRNA substrates
	interacting with CCR2, followed by CCR2 receptor internalization
	HNRNPA1 preferentially binds TNPO1, TNPO2
	interacting with CD44
	FUS bind the import-karyopherin, karyopherinbeta2 (TNPO1) in a RAN-sensitive manner
	TNPO1 mediates YBX1 nuclear translocation
	O-GlcNAcylation, regulates likely HNRNPA1 translocation and interaction with TNPO1, possibly affecting its function
	interaction of TNPO1 and TNPO3 with the nonclassical NLSs may regulate the formation of membraneless organelles and subcellular localization of numerous protein
	mechanistically, TNPO1 is selectively responsible for nuclear import of ARID1B, which is a synthetic lethal target in ARID1A-inactivating mutation cancers

cell & other

REGULATION

inhibited by

NUP98

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS