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FLASH GENE
Symbol KPNA5 contributors: - updated : 23-09-2004
HGNC name karyopherin alpha 5 (importin alpha 6)
HGNC id 6398
PROTEIN
PHYSICAL PROPERTIES acid
STRUCTURE
motifs/domains
  • N terminal importin beta binding domain
  • eight armadillo/beta catenin-like repeats
  • C terminal acidic region
    • HOMOLOGY
    interspecies homolog to C-Elegans Ima2
    intraspecies homolog to SRP1 (KPNA1)
    Homologene
    FAMILY importin alpha protein family
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • involved in nuclear localization signal(NLS)- dependent protein import into the nucleus
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the NLS import receptor including an heterodimer of importin alpha and beta
    • INTERACTION
    DNA
    RNA
    small molecule
    protein binding the nuclear localization signal NLS of nuclear proteins
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS