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FLASH GENE
Symbol KPNA5 contributors: - updated : 23-09-2004
HGNC name karyopherin alpha 5 (importin alpha 6)
HGNC id 6398
Location 6q22.31      Physical location : 117.002.366 - 117.063.029
Synonym name
  • RAG cohort 1
  • importin alpha 6
  • Synonym symbol(s) RCH1, SRP1ALPHA, IMA5
    DNA
    TYPE functioning gene
    STRUCTURE 43.00 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    Reproductivemale systemtestis   
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text eye
    PROTEIN
    PHYSICAL PROPERTIES acid
    STRUCTURE
    motifs/domains
  • N terminal importin beta binding domain
  • eight armadillo/beta catenin-like repeats
  • C terminal acidic region
  • HOMOLOGY
    interspecies homolog to C-Elegans Ima2
    intraspecies homolog to SRP1 (KPNA1)
    Homologene
    FAMILY importin alpha protein family
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • involved in nuclear localization signal(NLS)- dependent protein import into the nucleus
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the NLS import receptor including an heterodimer of importin alpha and beta
  • INTERACTION
    DNA
    RNA
    small molecule
    protein binding the nuclear localization signal NLS of nuclear proteins
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS