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FLASH GENE

Symbol

KPNA5

contributors: - updated : 23-09-2004

HGNC name	karyopherin alpha 5 (importin alpha 6)
HGNC id	6398

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	6q22.31      Physical location : 117.002.366 - 117.063.029
Synonym name	RAG cohort 1
	importin alpha 6
Synonym symbol(s)	RCH1, SRP1ALPHA, IMA5

DNA

TYPE	functioning gene
STRUCTURE	43.00 kb     13 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain         Reproductive male system testis       Respiratory lung

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text

eye

PROTEIN

PHYSICAL PROPERTIES		acid
STRUCTURE

motifs/domains	N terminal importin beta binding domain
	eight armadillo/beta catenin-like repeats
	C terminal acidic region

HOMOLOGY

interspecies

homolog to C-Elegans Ima2

intraspecies

homolog to SRP1 (KPNA1)

Homologene

FAMILY

importin alpha protein family

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus

basic FUNCTION

involved in nuclear localization signal(NLS)- dependent protein import into the nucleus

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

component of the NLS import receptor including an heterodimer of importin alpha and beta

INTERACTION

DNA

RNA

small molecule

protein

binding the nuclear localization signal NLS of nuclear proteins

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS