Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol KPNA6 contributors: mct - updated : 11-02-2012
HGNC name karyopherin alpha 6 (importin alpha 7)
HGNC id 6399
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • importin beta binding domain
  • Armadillo/beta-catenin-like repeats domain
    • HOMOLOGY
    interspecies homolog to murine Kpna6
    Homologene
    FAMILY
  • importin alpha protein family
    • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • playing a role in nuclear import
  • KPNA6-mediated KEAP1 nuclear import plays an essential role in modulating the NFE2L2-dependent antioxidant response and maintaining cellular redox homeostasis
  • involved in the nuclear import of proteins, contributing to spindle assembly and nuclear membrane formation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
  • component of the NLS import receptor including an heterodimer of importin alpha and beta
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding the nuclear localization signal NLS of nuclear proteins
  • directly interacts with the Kelch domain of KEAP1
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mouse embryos lacking importin &
    • 945;7 display a reduced ability for the first cleavage and arrest completely at the two-cell stage