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FLASH GENE
Symbol KPNA6 contributors: mct - updated : 11-02-2012
HGNC name karyopherin alpha 6 (importin alpha 7)
HGNC id 6399
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver    
Endocrinepancreas    
Nervousbrain    
Reproductivemale systemprostate   
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • importin beta binding domain
  • Armadillo/beta-catenin-like repeats domain
    • HOMOLOGY
    interspecies homolog to murine Kpna6
    Homologene
    FAMILY
  • importin alpha protein family
    • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • playing a role in nuclear import
  • KPNA6-mediated KEAP1 nuclear import plays an essential role in modulating the NFE2L2-dependent antioxidant response and maintaining cellular redox homeostasis
  • involved in the nuclear import of proteins, contributing to spindle assembly and nuclear membrane formation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
  • component of the NLS import receptor including an heterodimer of importin alpha and beta
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding the nuclear localization signal NLS of nuclear proteins
  • directly interacts with the Kelch domain of KEAP1
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mouse embryos lacking importin &
    • 945;7 display a reduced ability for the first cleavage and arrest completely at the two-cell stage