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FLASH GENE

Symbol

KPNA6

contributors: mct - updated : 11-02-2012

HGNC name	karyopherin alpha 6 (importin alpha 7)
HGNC id	6399

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1p35.1      Physical location : 32.573.643 - 32.642.166
Synonym name	karyopherin subunit alpha-6
	importin-alpha-S2
Synonym symbol(s)	IPOA7, MGC17918, FLJ11249

DNA

TYPE	functioning gene
STRUCTURE	68.53 kb     14 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_012316 14 - 7373 60 536 - 1997 9395085

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive liver         Endocrine pancreas         Nervous brain         Reproductive male system prostate       Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	importin beta binding domain
	Armadillo/beta-catenin-like repeats domain

HOMOLOGY

interspecies

homolog to murine Kpna6

Homologene

FAMILY

importin alpha protein family

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus

basic FUNCTION	playing a role in nuclear import
	KPNA6-mediated KEAP1 nuclear import plays an essential role in modulating the NFE2L2-dependent antioxidant response and maintaining cellular redox homeostasis
	involved in the nuclear import of proteins, contributing to spindle assembly and nuclear membrane formation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

cellular trafficking transport

PATHWAY

metabolism

signaling

a component

component of the NLS import receptor including an heterodimer of importin alpha and beta

INTERACTION

DNA

RNA

small molecule

protein	binding the nuclear localization signal NLS of nuclear proteins
	directly interacts with the Kelch domain of KEAP1

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

	mouse embryos lacking importin &
	945;7 display a reduced ability for the first cleavage and arrest completely at the two-cell stage