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FLASH GENE
Symbol PIK3CB contributors: mct/npt/pgu - updated : 19-04-2016
HGNC name phosphoinositide-3-kinase, catalytic, beta polypeptide
HGNC id 8976
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • C2 domain
  • a PI3K/PI4K domain
    • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies ortholog to rattus Pik3cb
    ortholog to murine Pik3cb
    Homologene
    FAMILY
  • PI3/PI4-kinase family
    • CATEGORY enzyme , signaling , receptor membrane
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • playing a role in RAS activation
  • playing a key role in regulating the formation and stability of integrin alpha(IIb)beta(3) adhesion bonds, necessary for shear activation of platelets
  • with PIK3CA, regulate S-phase entry
  • critical for cell growth and survival
  • plays an essential role in GP6-mediated platelet aggregation and Akt activation
  • positively controls LPS-induced IL12 production through the JNK1-dependent pathway in human macrophages and dendritic cells
  • PIK3R1 and PIK3CB are essential for androgen-stimulated androgen receptor transactivation, and their aberrant expression or activation might play an important role in prostate cancer progression
    • CELLULAR PROCESS cell cycle, progression
    PHYSIOLOGICAL PROCESS coagulation/hemostasis
    text regulation of progression through cell cycle
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • heterodimer of a p110 (catalytic) and a p85 (regulatory) subunit
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CRKL mediates PIK3CB-dependent PI3K signaling in PTEN-deficient cancer cells
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene important new target for antithrombotic therapy
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    PI3K inhibitor that is capable of inhibiting the p110beta isoform (PIK3CB) can treat patients with PTEN-negative tumors
    ANIMAL & CELL MODELS