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FLASH GENE
Symbol SPRR2D contributors: - updated : 18-03-2006
HGNC name small proline-rich protein 2D
HGNC id 11264
Location 1q21-q22      Physical location : 153.012.200 - 153.013.594
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
text clustered in the epidermal differentiation complex (EDC)
text structure open reading frame in a single exon
MAPPING cloned Y linked N status confirmed
Map cen - SPRR4 - SPRR1A - SPRR3 - SPRR1B - SPRR2D - SPRR2A - SPRR2B - SPRR2E - SPRR2F - SPRR2C - SPRR2G - tel
Authors Cabral et al.(01)
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus    
 mouthtongue   
 pharynx   highly
Respiratoryrespiratory tractlarynx   
cell lineage precursor of cornified cell envelope
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a central segment built up from nine octapeptide repeats,*K*PEP*
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    text cornifin
    basic FUNCTION keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component clustered in the epidermal differentiation complex (EDC)
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by during squamous differentiation of epidermal keratinocytes
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS