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FLASH GENE

Symbol

NRG3

contributors: mct - updated : 06-09-2016

HGNC name	neuregulin 3
HGNC id	7999

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

DEL10Q23

Susceptibility

to schizophrenia to developmental delay, cognitive impairment, and autism to Hirschsprung disease

Variant & Polymorphism SNP	polymorphisms in intron 1 of NRG3 (rs10883866, rs10748842, and rs6584400) increasing the risk of schizophrenia
	recurrent microdeletions associated with a heterogeneous group of neurodevelopmental disorders, including developmental delay, cognitive impairment, and autism
	nonsynonymous variant c.1329G>A (p.M443I) and synonymous variants c.828G>A (p.T276T) and c.1365T>A (p.P455P) increase risk of Hirschsprung disease

Candidate gene	for congenital breast aplasia in del 10q23
Marker
Therapy target

ANIMAL & CELL MODELS

in murine juvenile testes Ra and Fsh induced meiosis indirectly through Sertoli cells when Nrg1 and Nrg3 were upregulated, as Nrg1 amplified itself and Nrg3