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FLASH GENE
Symbol TRIM39 contributors: mct - updated : 27-02-2020
HGNC name tripartite motif containing 39
HGNC id 10065
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N terminal Ring-type zinc finger, Tripartite Motif (TRIM), consisting of RING domain, B-box and coiled-coil domain
  • a myosin tail
  • a B30.2/SPRY domain
    • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to rattus Trim39 (97.5 pc)
    homolog to murine Trim39 (97.8 pc)
    Homologene
    FAMILY
  • B box family
  • TRIM/RBCC family
  • C-IV TRIM family
    • CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • sensitizes cells to etoposide-induced apoptosis
  • can promote apoptosis signalling through stabilization of MOAP1
  • influence of TRIM39 on MOAP1 levels stems from the ability of TRIM39 (a RING domain E3 ligase) to directly inhibit APC/C(Cdh1)-mediated protein ubiquitylation
  • causal role for TRIM39 in regulating cell cycle progression and the balance between cytostasis and apoptosis after DNA damage via stabilizing CDKN1A
  • TRIM39 is a unique E3 ligase directly regulating TP53 stability
  • is a regulator of several key processes in the proliferative cycle
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
  • MOAP1-binding protein (extends the half-life of MOAP-1 by inhibiting its poly-ubiquitination process)
  • CDKN1A is a crucial downstream effector of TRIM39 mediating G1/S transition and DNA damage-induced G2 arrest
  • TRIM39 can directly bind and ubiquitylate TP53, leading to TP53 degradation
  • TRIM39 stabilizes CACTIN protein and CACTIN is upregulated after TNF stimulation
  • TRIM39 negatively regulates the NFKB1 signal in collaboration with CACTIN induced by inflammatory stimulants such as TNF
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to Behcet disease (BD)
    Variant & Polymorphism SNP rs2074474 on exon 9 of tripartite motif-containing (TRIM39) associated with Behcet disease (BD)
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    dermatologyskin 
    therapeutic target against Behcet disease
    ANIMAL & CELL MODELS