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FLASH GENE

Symbol

TRIM39

contributors: mct - updated : 27-02-2020

HGNC name	tripartite motif containing 39
HGNC id	10065

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	17.26 kb     9 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

regionally located

in the MHC class I cluster

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_021253 9 splicing 3354 NP_067076 59 518 - 2016 26363554 NM_172016 8 splicing 3578 NP_742013 56 488 - 2016 26363554 lacking an in-frame exon in the coding region NM_001369523 9 - 3669 NP_001356452 - 488 - 2016 26363554 NM_001369521 8 - 3624 NP_001356450 - 488 - 2016 26363554 NM_001369522 8 - 3516 NP_001356451 - 488 - 2016 26363554

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine neuroendocrine pituitary     moderately   thyroid       predominantly Lymphoid/Immune lymph node       moderately Reproductive female system uterus cervix   moderately   male system testis     highly

cell lineage
cell lines
fluid/secretion	moderately in blood

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an N terminal Ring-type zinc finger, Tripartite Motif (TRIM), consisting of RING domain, B-box and coiled-coil domain
	a myosin tail
	a B30.2/SPRY domain

conjugated

PhosphoP

HOMOLOGY

interspecies	homolog to rattus Trim39 (97.5 pc)
	homolog to murine Trim39 (97.8 pc)

Homologene

FAMILY	B box family
	TRIM/RBCC family
	C-IV TRIM family

CATEGORY

DNA associated , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION	sensitizes cells to etoposide-induced apoptosis
	can promote apoptosis signalling through stabilization of MOAP1
	influence of TRIM39 on MOAP1 levels stems from the ability of TRIM39 (a RING domain E3 ligase) to directly inhibit APC/C(Cdh1)-mediated protein ubiquitylation
	causal role for TRIM39 in regulating cell cycle progression and the balance between cytostasis and apoptosis after DNA damage via stabilizing CDKN1A
	TRIM39 is a unique E3 ligase directly regulating TP53 stability
	is a regulator of several key processes in the proliferative cycle

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	Zn2+

protein	MOAP1-binding protein (extends the half-life of MOAP-1 by inhibiting its poly-ubiquitination process)
	CDKN1A is a crucial downstream effector of TRIM39 mediating G1/S transition and DNA damage-induced G2 arrest
	TRIM39 can directly bind and ubiquitylate TP53, leading to TP53 degradation
	TRIM39 stabilizes CACTIN protein and CACTIN is upregulated after TNF stimulation
	TRIM39 negatively regulates the NFKB1 signal in collaboration with CACTIN induced by inflammatory stimulants such as TNF

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to Behcet disease (BD)

Variant & Polymorphism SNP	rs2074474 on exon 9 of tripartite motif-containing (TRIM39) associated with Behcet disease (BD)

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed dermatology skin   therapeutic target against Behcet disease

ANIMAL & CELL MODELS