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FLASH GENE
Symbol SPRR2B contributors: - updated : 12-05-2006
HGNC name small proline-rich protein 2B
HGNC id 11262
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a central segment built up from nine octapeptide repeats,*K*PEP*
HOMOLOGY
Homologene
FAMILY cornifin (SPRR) family
CATEGORY structural protein
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytoskeleton
text cornifin
basic FUNCTION
  • involved in the differentiation of epidermal keratinocytes
  • keratinocyte protein that first appears in the cell
    • cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component clustered in the epidermal differentiation complex (EDC)
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by by UV irradiation and carcinogenic agents
    during squamous differentiation of epidermal keratinocytes
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS