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FLASH GENE

Symbol

SPRR2B

contributors: - updated : 12-05-2006

HGNC name	small proline-rich protein 2B
HGNC id	11262

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
text	clustered in the epidermal differentiation complex (EDC)
STRUCTURE	1.00 kb     2 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

text structure

open reading frame in a single exon

MAPPING

cloned

Y

linked

N

status

confirmed

Map	cen - SPRR4 - SPRR1A - SPRR3 - SPRR1B - SPRR2D - SPRR2A - SPRR2B - SPRR2E - SPRR2F - SPRR2C - SPRR2G - tel
Authors	Cabral et al.(01)

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive esophagus           pharynx         Skin/Tegument skin appendages

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial barrier/lining epidermis stratum granulosum

cell lineage	precursor of cornified cell envelope
cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a central segment built up from nine octapeptide repeats,*K*PEP*

HOMOLOGY

Homologene

FAMILY

cornifin (SPRR) family

CATEGORY

structural protein

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton
text	cornifin

basic FUNCTION	involved in the differentiation of epidermal keratinocytes
	keratinocyte protein that first appears in the cell
	cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

clustered in the epidermal differentiation complex (EDC)

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

induced by	by UV irradiation and carcinogenic agents
		during squamous differentiation of epidermal keratinocytes

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS