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FLASH GENE
Symbol TGIF2 contributors: mct - updated : 29-03-2019
HGNC name TGFB-induced factor 2 (TALE family homeobox)
HGNC id 15764
Location 20q11.23      Physical location : 35.202.009 - 35.222.350
DNA
TYPE functioning gene
STRUCTURE 20.48 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
text structure
  • contains a retained intron, within the second coding exon
  • MAPPING cloned Y linked N status provisional
    Physical map
    LOC375095 20q11.23 similar to dJ309K20.1.1 (novel protein similar to dysferlin, isoform 1) SPAG4 20q11.2 sperm associated antigen 4 CPNE1 20q11.21 copine I RBM12 20q11.21 RNA binding motif protein 12 NFS1 20q11-q12 NFS1 nitrogen fixation 1 (S. cerevisiae) C20orf52 20q11.23 chromosome 20 open reading frame 52 RNPC2 20q11.21 RNA-binding region (RNP1, RRM) containing 2 C20orf53 20 chromosome 20 open reading frame 53 C20orf104 20q11.22-q11.23 chromosome 20 open reading frame 104 SCAND1 20q11.1-q11.23 SCAN domain containing 1 C20orf152 20q11.23 chromosome 20 open reading frame 152 HMG4L2 20q11.23 high-mobility group (nonhistone chromosomal) protein 4-like 2 EPB41L1 20q11.2-q12 erythrocyte membrane protein band 4.1-like 1 C20orf4 20pter-q12 chromosome 20 open reading frame 4 DAP4 20q11.23 disks large-associated protein 4 MYL9 20q11.22 myosin, light polypeptide 9, regulatory TGIF2 20q11.2-q12 TGFB-induced factor 2 (TALE family homeobox) C20orf24 20q11.23 chromosome 20 open reading frame 24 SLA2 20q11.22 Src-like-adaptor 2 NDRG3 20q11.21-q11.23 NDRG family member 3 C20orf172 20q11.23 chromosome 20 open reading frame 172 KIAA0889 20q11.23 KIAA0889 protein LOC343574 20q11.23 similar to dJ132F21.2 (Contains a novel protein similar to the L82E from Drosophila) SAMHD1 20q11.22 SAM domain and HD domain 1 RBL1 20q11.21 retinoblastoma-like 1 (p107) RPS3AP3 20q11.2 ribosomal protein S3A pseudogene 3 C20orf132 20q11.22 chromosome 20 open reading frame 132 RPN2 20q11.22-q11.23 ribophorin II GHRH 20q11.21 growth hormone releasing hormone MANBAL 20q11.23-q12 mannosidase, beta A, lysosomal-like SRC 20q11.21 v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 3456 - 237 - 2017 27956704
    3 - 3328 - 237 - 2017 27956704
    3 - 3415 - 237 - 2017 27956704
    3 - 3358 - 237 - 2017 27956704
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveintestinesmall intestine  highly
     intestinelarge intestinecolon highly
     liver   highly
     mouthtongue  highly
     pancreas exocrine   moderately
    Lymphoid/Immunelymph node   predominantly
    Reproductivefemale systemovary  highly
     male systemtestis  moderately
     male systemprostate  moderately
    Respiratorylung   moderately
     lung   highly
     respiratory tractlarynx  moderately
    Skin/Tegumentskin   highly
    Urinarykidney    
    Visualeye   moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • putative nuclear localization signal (NLS) helix turn helix
  • DNA binding domain
  • three AA loop extension between helices superfamily (TALE)
  • one proline-rich domain
  • HOMOLOGY
    interspecies ortholog to murine Tgif2
    intraspecies homolog to TGIF
    Homologene
    FAMILY TALE family homeobox
    CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • acting as a transcriptional repressor when bound to DNA via aTGIF binding site and recruiting histone deacetylase
  • TGIF2 acts primarily by restricting BMP signaling in the endoderm to allow pancreatic formation
  • is the molecular link between dorsoventral patterning of the endoderm and pancreatic specification
  • TGIF1, TGIF2 are transcriptional co-repressors that limit the response to TGFbeta signaling and play a role in regulating retinoic-acid-mediated gene expression
  • TGIF1, TGIF2 function is required for gastrulation, and provide the first clear evidence that Tgifs limit the transcriptional response to NODAL signaling during early embryogenesis
  • TGIF1, TGIF2 are transcriptional repressors that inhibit the transcriptional response to TGFB1 signaling, and can repress gene expression by direct binding to DNA
  • TGIF1, TGIF2 regulate axial patterning and reduced TGIF function sensitizes embryos to the effects of retinoic acid
  • participates likely in photoreceptor cell differentiation in the early stages of retinal development and regulates proper subretinal localization of the cone photoreceptors
  • TGIF1, TGIF2 regulate ciliogenesis and EVI5L mediates likely at least part of this effect
  • TGIF1, TGIF2 play an important role in regulating basic energy metabolism in normal cells, and this function of Tgifs is amplified in some cancers
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • histone deacetylase
  • TGIF1 and TGIF2 regulate the TGFB1/NODAL signaling pathway and sonic hedgehog (SHH) signaling independently
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification --over  
    in ovarian cancers cell lines
    constitutional germinal mutation     loss of function
    in both TGIF1 and TGIF2 result in a failure of gastrulation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS