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FLASH GENE

Symbol

SPRR1B

contributors: mct - updated : 19-11-2014

HGNC name	small proline-rich protein 1B (cornifin)
HGNC id	11260

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in oral squamous cell cancer stem-like cells

Susceptibility

to psoriasis (see PSORS4)

Variant & Polymorphism

Candidate gene
Marker	biomarker for squamous metaplasia in dry eye disease
Therapy target

ANIMAL & CELL MODELS

Sprr1b was increased across the ocular surface of mice with both desiccating stress and autoimmune-mediated, aqueous-deficient dry eye and in patients with Sjögren syndrome (SS)