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FLASH GENE
Symbol SPRR1B contributors: mct - updated : 19-11-2014
HGNC name small proline-rich protein 1B (cornifin)
HGNC id 11260
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • small proline rich protein
  • a central segment built up from eight octapeptide repeats, *K*PEP*
    • HOMOLOGY
    Homologene
    FAMILY cornifin (SPRR) family
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    text cornifin
    basic FUNCTION
  • keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase
  • role of SPRR1B during squamous differentiation of skin and respiratory epithelial cells
  • likely coupled primarily to signals responsible for withdrawal from the proliferative state rather than the final stages of cellular quiescence
  • having a role in the cell growth of oral squamous cell carcinoma stem cells
  • has a role in cell growth by suppression of RASSF4
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component clustered in the epidermal differentiation complex (EDC)
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • enhance MAPK signal by suppression of tumor suppressor RASSF4
    • cell & other
    REGULATION
    induced by by carcinogenic agents and by UV light
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in oral squamous cell cancer stem-like cells
    Susceptibility to psoriasis (see PSORS4)
    Variant & Polymorphism
    Candidate gene
    Marker
  • biomarker for squamous metaplasia in dry eye disease
    • Therapy target
    ANIMAL & CELL MODELS
  • Sprr1b was increased across the ocular surface of mice with both desiccating stress and autoimmune-mediated, aqueous-deficient dry eye and in patients with Sjögren syndrome (SS)