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FLASH GENE

Symbol

SPRR1B

contributors: mct - updated : 19-11-2014

HGNC name	small proline-rich protein 1B (cornifin)
HGNC id	11260

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
text	clustered in the epidermal differentiation complex (EDC), with SPRR1A, SPRR3, SPRR2A, SPRR2B, SPRR2C, SPRR2D, SPRR2E, SPRR2F, SPRR2G, SPRR4
STRUCTURE	1.59 kb     2 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

text structure

open reading frame in a single exon

MAPPING

cloned

Y

linked

status

confirmed

Map	cen - SPRR4 - SPRR1A - SPRR3 - SPRR1B - SPRR2D - SPRR2A - SPRR2B - SPRR2E - SPRR2F - SPRR2C - SPRR2G - tel
Authors	Cabral 01)
Text	see EDC@

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_003125 2 - 641 NP_003116 14.9 89 - 2003 12832281

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive esophagus         Homo sapiens   mouth tongue       Homo sapiens   pharynx         Respiratory respiratory tract larynx       Skin/Tegument skin         Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial barrier/lining

cells

System Cell Pubmed Species Stage Rna symbol Skin/Tegument keratinocyte

cell lineage	precursor of cornified cell envelope
cell lines
fluid/secretion

at STAGE

physiological period

Text	during differentiation of squamous cells

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	small proline rich protein
	a central segment built up from eight octapeptide repeats, *K*PEP*

HOMOLOGY

Homologene

FAMILY

cornifin (SPRR) family

CATEGORY

structural protein

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton
text	cornifin

basic FUNCTION	keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase
	role of SPRR1B during squamous differentiation of skin and respiratory epithelial cells
	likely coupled primarily to signals responsible for withdrawal from the proliferative state rather than the final stages of cellular quiescence
	having a role in the cell growth of oral squamous cell carcinoma stem cells
	has a role in cell growth by suppression of RASSF4

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

clustered in the epidermal differentiation complex (EDC)

INTERACTION

DNA

RNA

small molecule

protein

enhance MAPK signal by suppression of tumor suppressor RASSF4

cell & other

REGULATION

induced by

by carcinogenic agents and by UV light

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in oral squamous cell cancer stem-like cells

Susceptibility

to psoriasis (see PSORS4)

Variant & Polymorphism

Candidate gene
Marker	biomarker for squamous metaplasia in dry eye disease
Therapy target

ANIMAL & CELL MODELS

Sprr1b was increased across the ocular surface of mice with both desiccating stress and autoimmune-mediated, aqueous-deficient dry eye and in patients with Sjögren syndrome (SS)