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FLASH GENE

Symbol

SPRR2A

contributors: - updated : 08-04-2006

HGNC name	small proline-rich protein 2A
HGNC id	11261

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive esophagus           mouth tongue         pharynx         Respiratory respiratory tract larynx

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow

cell lineage	precursor of cornified cell envelope
cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a central segment built up from nine octapeptide repeats, *K*PEP*

HOMOLOGY

Homologene

FAMILY

cornifin (SPRR) family

CATEGORY

structural protein

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton
text	cornifin

basic FUNCTION

cross-linked envelope protein of keratinocytes, involved in keratinocytes differentiation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

clustered in the epidermal differentiation complex (EDC)

INTERACTION

DNA

RNA

small molecule

protein

cell & other

associating with the nuclear matrix

REGULATION

induced by

during squamous differentiation of epidermal keratinocytes

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS