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FLASH GENE

Symbol

SPRR3

contributors: shn - updated : 29-03-2011

HGNC name	small proline-rich protein 3
HGNC id	11268

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a central segment built up from eight octapeptide repeats, *K*PEP*

HOMOLOGY

interspecies	ortholog to Sprr3, Mus musculus
	ortholog to Sprr3, Rattus norvegicus
	ortholog to SPRR3, Pan troglodytes

Homologene

FAMILY

SPRR family of cornified envelope precursor proteins

CATEGORY

structural protein

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton
text	cornifin

basic FUNCTION	cross-linked envelope protein of keratinocytes
	keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase
	function as a flexible cross-bridging protein to provide tensile strength or rigidity to the cell envelope of the stratified squamous epithelia

CELLULAR PROCESS	cell life, differentiation

PHYSIOLOGICAL PROCESS

text	squamous cell differentiation

PATHWAY

metabolism

signaling

a component

clustered in the epidermal differentiation complex (EDC)

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

induced by	the extracellular calcium (during esophageal epithelial cell differentiation)
		during squamous metaplasia induced by cigarette smoke exposure

Other

regulated by prolonged cyclic stress in vascular smooth muscle cells, which may have important implications to vascular disease

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in primary esophageal squamous cell carcinoma and in areas of cellular dysplasia

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS