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FLASH GENE

Symbol

MIS18A

contributors: mct - updated : 03-12-2011

HGNC name	MIS18 kinetochore protein homolog A (S. pombe)
HGNC id	1286

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_018944 5 - 1587 - 233 - 2007 17199038

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Lymphoid/Immune lymph node         Reproductive male system prostate

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

CATEGORY

unknown/unspecified

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,nucleoplasm
	intracellular,nucleus,chromatin/chromosome,centromere

basic FUNCTION	essential role for centromere/kinetochore structure and function
	centromeric localization of MIS18 complex is essential for the subsequent recruitment of de novo-synthesized CENPA

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

MIS18A/MIS18BP1/OIP5 complex (MIS18 complex) is accumulated specifically at the telophase-G1 centromere

INTERACTION

DNA

RNA

small molecule

protein

interaction between MAFIP and MIS18A

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS