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FLASH GENE
Symbol MIS18A contributors: mct - updated : 03-12-2011
HGNC name MIS18 kinetochore protein homolog A (S. pombe)
HGNC id 1286
Location 21q22.11      Physical location : -
Synonym name
  • FAPP1-associated protein 1
  • MAFIP-interacting protein FAPP1 (phosphatidylinositol-four-phosphate adaptor protein1) associated protein-1)
  • chromosome 21 open reading frame 46
  • chromosome 21 open reading frame 45
    • Synonym symbol(s) B28, FASP1, C21orf46, c21orf45, MIS18alpha, hMis18alpha
    DNA
    TYPE functioning gene
    STRUCTURE 10.85 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1587 - 233 - 2007 17199038
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Lymphoid/Immunelymph node    
    Reproductivemale systemprostate   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome,centromere
    basic FUNCTION
  • essential role for centromere/kinetochore structure and function
  • centromeric localization of MIS18 complex is essential for the subsequent recruitment of de novo-synthesized CENPA
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component MIS18A/MIS18BP1/OIP5 complex (MIS18 complex) is accumulated specifically at the telophase-G1 centromere
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction between MAFIP and MIS18A
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS