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FLASH GENE
Symbol FAM3B contributors: SGE/npt - updated : 05-01-2007
HGNC name family with sequence similarity 3, member B
HGNC id 1253
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • one hydrophobic leader sequence
  • four conserved cysteine
  • two glycosylation sites
    • secondary structure 4 alpha-helical bundles with an up-up-down-down topology, and two disulfide bonds (helices B and C and the second disulfide bond are essential for PANDER-induced beta-cell death)
    HOMOLOGY
    interspecies homolog to murine Orf9
    intraspecies homolog to FAM3C
    Homologene
    FAMILY
  • FAM3 family
    • CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • may be having a role in the process of pancreatic beta-cell apoptosis
  • may play a role in glucose homeostasis in combination with or without insulin
  • cytokine, present in insulin secretory granules, inducing apoptosis of alpha and beta cells islets in a dose- and time-dependent manner, and may be implicated in diabetes
    • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
  • binding to the liver cell membrane (Yang 2009)
    • REGULATION
    inhibited by over-expression of CLN3 in neuroblastoma cells
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    in diabetes
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS