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FLASH GENE
Symbol PSMA7 contributors: mct - updated : 04-10-2014
HGNC name proteasome (prosome, macropain) subunit, alpha type, 7
HGNC id 9536
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Psma7
intraspecies homolog to PSMA2
Homologene
FAMILY proteasome a-type family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
intracellular,nucleus,nucleoplasm
basic FUNCTION
  • involved in an ATP/ubiquintin-dependent non-lysosomal proteolytic pathway
  • be a target interacting with some important proteins involved in transcription factor regulation, cell cycle transition, viral replication and even tumor initiation and progression
    • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    text proteoysis and peptidolysis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • HBX (interfere with activities of the proteasome complex)
  • CRYAB
  • AIMP1 into the cytoplasmic compartment interacts with its cytoplasmic partner PSMA7, a component of the proteasome degradation pathway
  • PSMA7 is a negative regulator of the MAVS-mediated innate immunity that probably serves to attenuate the establishment of an antiviral state during viral infection
  • PPP3R1 binds to proteasome subunit alpha type 7 (PSMA7) and inhibits the transactivation activity of HIF1A via the proteasome pathway
  • PSMA7 is a negative regulator of the NOD1, and may promote tumor growth by its inhibitory role on NOD1
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colorectal cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • is a potential tumor biomarker
    • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivecolon
    pharmacological inhibition of PSMA7 may be a beneficial strategy in the treatment of colorectal cancer patients
    ANIMAL & CELL MODELS