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FLASH GENE
Symbol PSMA7 contributors: mct - updated : 04-10-2014
HGNC name proteasome (prosome, macropain) subunit, alpha type, 7
HGNC id 9536
Location 20q13.33      Physical location : 60.711.790 - 60.718.474
Synonym name
  • proteasome subunit RC6-1
  • proteasome subunit XAPC7
    • Synonym symbol(s) XAPC7, PSA7, C6, HSPC, MGC3755, RC6-1
    EC.number 3.4.25.1
    DNA
    TYPE functioning gene
    STRUCTURE 6.73 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 1050 - 248 - 2008 18202793
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemovary  highly
     female systemuteruscervix highly
     male systemprostate  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines several cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Psma7
    intraspecies homolog to PSMA2
    Homologene
    FAMILY proteasome a-type family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • involved in an ATP/ubiquintin-dependent non-lysosomal proteolytic pathway
  • be a target interacting with some important proteins involved in transcription factor regulation, cell cycle transition, viral replication and even tumor initiation and progression
    • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    text proteoysis and peptidolysis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • HBX (interfere with activities of the proteasome complex)
  • CRYAB
  • AIMP1 into the cytoplasmic compartment interacts with its cytoplasmic partner PSMA7, a component of the proteasome degradation pathway
  • PSMA7 is a negative regulator of the MAVS-mediated innate immunity that probably serves to attenuate the establishment of an antiviral state during viral infection
  • PPP3R1 binds to proteasome subunit alpha type 7 (PSMA7) and inhibits the transactivation activity of HIF1A via the proteasome pathway
  • PSMA7 is a negative regulator of the NOD1, and may promote tumor growth by its inhibitory role on NOD1
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colorectal cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • is a potential tumor biomarker
    • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivecolon
    pharmacological inhibition of PSMA7 may be a beneficial strategy in the treatment of colorectal cancer patients
    ANIMAL & CELL MODELS