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FLASH GENE
Symbol GMFG contributors: mct/np - updated : 10-01-2009
HGNC name glia maturation factor, gamma
HGNC id 4374
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a ADF-H domain
HOMOLOGY
Homologene
FAMILY
  • actin-binding proteins ADF family
  • GMF subfamily
    • CATEGORY signaling cytokine growth factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus,nucleolus
    text in endothelial cells, GMFG was colocalized with F-actin in membrane ruffles
    basic FUNCTION
  • cytokine-responsive protein in erythropoietin-induced and granulocyte-colony stimulating factor-induced hematopoietic lineage development
  • hematopoietic-specific protein that may mediate the pluripotentiality and lineage commitment of human hematopoietic stem cells
  • enhancing actin-based cellular functions such as migration and tube-formation in endothelial cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in cardiac ischemia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS