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FLASH GENE
Symbol ARL6IP5 contributors: mct/npt/pgu - updated : 06-05-2009
HGNC name ADP-ribosylation-like factor 6 interacting protein 5
HGNC id 16937
Location 3p14.1      Physical location : 69.134.089 - 69.155.237
Synonym name
  • dermal papilla derived protein 11
  • glutamate transporter EEAC1-associated protein
  • prenylated Rab acceptor protein 2
  • addicsin
  • PRA1 domain family 3
  • vitamin A responsive, cytoskeleton related
  • cytoskeleton-related vitamin A-responsive protein
  • putative MAPK activating protein PM27
  • PRA1 domain family 3
  • Synonym symbol(s) HSPC127, GTRAP3-18, jmx, DERP11, JWA, PRAF3, Aip-5, hp22, JM5, PRA2
    DNA
    TYPE like-sequence
    STRUCTURE 21.15 kb     3 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 2135 21.5 188 - 2002 12119102
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestivepharynx   highly
    Endocrineneuroendocrinepituitary  highly
     parathyroid   highly
    Nervousnerve   highly
    Reproductivemale systemprostate  highly
    Respiratorylung   highly
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a Rab-acceptor motif, indicating a function in vesicle formation at the Golgi complex
  • four transmembrane domains
  • cytosolic N and C termini
  • mono polymer polymer
    HOMOLOGY
    interspecies homolog to rattus Jwa
    homolog to rat glutamate transporter-associated protein 3-18 (GTRAP3-18)
    intraspecies homolog to PRAF2
    Homologene
    FAMILY
  • PRA1 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nucleus
    text
  • translocated into the nucleus by the carrier protein XRCC1 and co-localized with XRCC1 foci after oxidative DNA damage
  • basic FUNCTION
  • modulating the transport functions ascribed to SLC1A1
  • playing an important role in regulating the metabolic function of SLC1A1
  • involved in regulation of intracellular concentrations of taurine and glutamate
  • actively involved in the signal pathways of oxidative stress in the cells
  • may be involved in membrane trafficKing
  • signaling molecule, involved in the induction of differentiation of myeloid leukemia cells
  • regulator of ER protein trafficking
  • having the ability to regulate the trafficking of selected additional neuron-transmitter transporters and receptors
  • ARL6IP5-regulated-tumor cellular migration might involve MAPK cascades activation and F-actin cytoskeleton rearrangement mechanisms
  • having a unexpected role in tumor cell migration behaviors
  • glutamate transport-associated protein for SLC1A1, interacting with SLC1A1 at the plasma membrane and thereby regulating neuronal glutathione levels
  • dominantly and negatively determining the intracellular glutathione contents in neurons
  • regulator of ER protein trafficking
  • involved in cellular responses to environmental stress including oxidative stress
  • may serve as a novel regulator of XRCC1 in the BER (base excision repair) protein complex to facilitate the repair of DNA single-strand breaks
  • structurally novel microtubule-associated protein, which regulates cancer cell migration via MAPK cascades and mediates differentiation of leukemic cells
  • recruited by XRCC1 to the DNA damage sites, mediates the repair of DNA damage induced by oxidative stress via activating the expression of XRCC1 through MAPK-E2F1 signaling pathway and protecting XRCC1 from ubiquitin-proteasome degradation
  • directly involved in the regulation of chronic morphine dependence
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    text glutamate transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to the C-terminal intracellular domain of SLC1A1
  • binding to prenylated RAB1A and RAB3A, and to the ADP- ribosylation like factor ARL6
  • putative negative modulator of Na+-dependent neural glutamate transporter-excitatory amino acid carrier 1 (EAAC1)
  • interact with SLC1A1 at the plasma membrane and thereby regulate neuronal glutathione levels
  • interaction of RAB1A and its regulator ARL6IP5 are involved in trafficking and neuronal differentiation
  • interacts with and reduces the activity of the neuronal specific Na(+)/K(+) glutamate transporter, SLC1A1
  • functioned as a repair protein by multi-interaction with XRCC1
  • regulates XRCC1 expression at both the transcriptional and post-translational levels
  • OPRD1 interacting with ARL6IP5 (ARL6IP5 is required for maintaining the stability of OPRD1 via the ubiquitin-proteasome pathway)
  • cell & other
    REGULATION
    activated by upon induced differentiation and in heat stress
    induced by retinoic acid
    methyl-beta-cyclodextrin
    Other responsive to heat shock, and oxidative stress
    not only regulated by ATRA but also by several other differentiation inducers such as phorbol-12-myristate-13-acetate (TPA), and hemin, involved in the mechanisms of differentiation along different lineages of myeloid leukemia cells
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS