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FLASH GENE

Symbol

ARL6IP5

contributors: mct/npt/pgu - updated : 06-05-2009

HGNC name	ADP-ribosylation-like factor 6 interacting protein 5
HGNC id	16937

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	3p14.1      Physical location : 69.134.089 - 69.155.237
Synonym name	dermal papilla derived protein 11
	glutamate transporter EEAC1-associated protein
	prenylated Rab acceptor protein 2
	addicsin
	PRA1 domain family 3
	vitamin A responsive, cytoskeleton related
	cytoskeleton-related vitamin A-responsive protein
	putative MAPK activating protein PM27
	PRA1 domain family 3
Synonym symbol(s)	HSPC127, GTRAP3-18, jmx, DERP11, JWA, PRAF3, Aip-5, hp22, JM5, PRA2

DNA

TYPE	like-sequence
STRUCTURE	21.15 kb     3 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_006407 3 - 2135 21.5 188 - 2002 12119102

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Digestive pharynx       highly Endocrine neuroendocrine pituitary     highly   parathyroid       highly Nervous nerve       highly Reproductive male system prostate     highly Respiratory lung       highly Urinary bladder       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a Rab-acceptor motif, indicating a function in vesicle formation at the Golgi complex
	four transmembrane domains
	cytosolic N and C termini

mono polymer

polymer

HOMOLOGY

interspecies	homolog to rattus Jwa
	homolog to rat glutamate transporter-associated protein 3-18 (GTRAP3-18)

intraspecies

homolog to PRAF2

Homologene

FAMILY

PRA1 family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,nucleus
text	translocated into the nucleus by the carrier protein XRCC1 and co-localized with XRCC1 foci after oxidative DNA damage

basic FUNCTION	modulating the transport functions ascribed to SLC1A1
	playing an important role in regulating the metabolic function of SLC1A1
	involved in regulation of intracellular concentrations of taurine and glutamate
	actively involved in the signal pathways of oxidative stress in the cells
	may be involved in membrane trafficKing
	signaling molecule, involved in the induction of differentiation of myeloid leukemia cells
	regulator of ER protein trafficking
	having the ability to regulate the trafficking of selected additional neuron-transmitter transporters and receptors
	ARL6IP5-regulated-tumor cellular migration might involve MAPK cascades activation and F-actin cytoskeleton rearrangement mechanisms
	having a unexpected role in tumor cell migration behaviors
	glutamate transport-associated protein for SLC1A1, interacting with SLC1A1 at the plasma membrane and thereby regulating neuronal glutathione levels
	dominantly and negatively determining the intracellular glutathione contents in neurons
	regulator of ER protein trafficking
	involved in cellular responses to environmental stress including oxidative stress
	may serve as a novel regulator of XRCC1 in the BER (base excision repair) protein complex to facilitate the repair of DNA single-strand breaks
	structurally novel microtubule-associated protein, which regulates cancer cell migration via MAPK cascades and mediates differentiation of leukemic cells
	recruited by XRCC1 to the DNA damage sites, mediates the repair of DNA damage induced by oxidative stress via activating the expression of XRCC1 through MAPK-E2F1 signaling pathway and protecting XRCC1 from ubiquitin-proteasome degradation
	directly involved in the regulation of chronic morphine dependence

CELLULAR PROCESS	cell life, differentiation

PHYSIOLOGICAL PROCESS

text	glutamate transport

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	binding to the C-terminal intracellular domain of SLC1A1
	binding to prenylated RAB1A and RAB3A, and to the ADP- ribosylation like factor ARL6
	putative negative modulator of Na+-dependent neural glutamate transporter-excitatory amino acid carrier 1 (EAAC1)
	interact with SLC1A1 at the plasma membrane and thereby regulate neuronal glutathione levels
	interaction of RAB1A and its regulator ARL6IP5 are involved in trafficking and neuronal differentiation
	interacts with and reduces the activity of the neuronal specific Na(+)/K(+) glutamate transporter, SLC1A1
	functioned as a repair protein by multi-interaction with XRCC1
	regulates XRCC1 expression at both the transcriptional and post-translational levels
	OPRD1 interacting with ARL6IP5 (ARL6IP5 is required for maintaining the stability of OPRD1 via the ubiquitin-proteasome pathway)

cell & other

REGULATION

activated by

upon induced differentiation and in heat stress

induced by	retinoic acid
		methyl-beta-cyclodextrin

Other	responsive to heat shock, and oxidative stress
	not only regulated by ATRA but also by several other differentiation inducers such as phorbol-12-myristate-13-acetate (TPA), and hemin, involved in the mechanisms of differentiation along different lineages of myeloid leukemia cells

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS