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FLASH GENE
Symbol CNIH contributors: mct - updated : 11-02-2011
HGNC name cornichon homolog (Drosophila)
HGNC id 19431
Location 14q22.2      Physical location : 54.893.646 - 54.908.148
Synonym name
  • T-cell growth-associated molecule 77
  • cornichon-like
  • Synonym symbol(s) TGAM77, CNIL, CNIH1, MGC117156
    DNA
    TYPE functioning gene
    STRUCTURE 14.50 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    GNPNAT1 14q22.1 glucosamine-phosphate N-acetyltransferase 1 PLEKHC1 14q22.1 pleckstrin homology domain containing, family C (with FERM domain) member 1 NDUFB3P3 14q22.3-q23.1 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa pseudogene 3 DDHD1 14q21 DDHD domain containing 1 BMP4 14q22-q23 bone morphogenetic protein 4 LOC341862 14q22.1 similar to ATP synthase gamma chain, mitochondrial precursor CDKN3 14q22 cyclin-dependent kinase inhibitor 3 (CDK2-associated dual specificity phosphatase) CNIH 14q22.1 cornichon homolog (Drosophila) GMFB 14q22.1 glia maturation factor, beta CGRRF1 14q22.1 cell growth regulator with ring finger domain 1 SAMD4 14q22.2 sterile alpha motif domain containing 4 GCH1 14q22.1-q22.2 GTP cyclohydrolase 1 (dopa-responsive dystonia) WDHD1 14q22.2 WD repeat and HMG-box DNA binding protein 1 SOCS7 14q22.2 suppressor of cytokine signaling 7 C14orf32 14q22.1 chromosome 14 open reading frame 32 LGALS3 14q21-q22 lectin, galactoside-binding, soluble, 3 (galectin 3) GALIG 14q21-q22 lectin, galactoside-binding, soluble, 3 (galectin 3) DLG7 14q22.1-q22.3 discs, large homolog 7 (Drosophila) UBE2L7 5p14.1 ubiquitin-conjugating enzyme E2L 7 pseudogene COX5AP1 14q22 cytochrome c oxidase subunit Va pseudogene 1 FBXO34 14q22.1 F-box only protein 34 KIAA0831 14q22.2 KIAA0831 HMGN1P1 14 high-mobility group nucleosome binding domain 1 pseudogene 1 LOC390477 14 similar to 60S ribosomal protein L7a (Surfeit locus protein 3) (PLA-X polypeptide) SSH3BP1P 14 spectrin SH3 domain binding protein 1 pseudogene KTN1 14q22 kinectin 1 (kinesin receptor) LOC390479 14 similar to ribosomal protein L13a; 60S ribosomal protein L13a; 23 kD highly basic protein LOC387989 14 LOC387989
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1423 16.6 144 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three transmembrane regions
  • HOMOLOGY
    interspecies homolog to cni Drosophila
    Homologene
    FAMILY
  • cornichon family
  • CATEGORY chaperone/stress , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    text
  • primarily localized in the endoplasmic reticulum
  • display a restricted distribution and are much less abundant than CACNG2
  • basic FUNCTION
  • part of conserved protein family that acts in the selective transport and maturation of TGFalpha family proteins
  • acting as chaperones for other proteins
  • can affect the trafficking of AMPARS (GRIA1, GRIA2, GRIA3, and GRIN2B), they were not detected on the surface of neurons and failed to alter the kinetics of endogenous AMPARs
  • can modestly enhance the surface expression of AMPARs in neurons, in the absence of CACNG2
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associate with immature TGFalpha family proteins
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS