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FLASH GENE
Symbol CNIH contributors: mct - updated : 11-02-2011
HGNC name cornichon homolog (Drosophila)
HGNC id 19431
Location 14q22.2      Physical location : 54.893.646 - 54.908.148
Synonym name
  • T-cell growth-associated molecule 77
  • cornichon-like
    • Synonym symbol(s) TGAM77, CNIL, CNIH1, MGC117156
    DNA
    TYPE functioning gene
    STRUCTURE 14.50 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1423 16.6 144 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three transmembrane regions
    • HOMOLOGY
    interspecies homolog to cni Drosophila
    Homologene
    FAMILY
  • cornichon family
    • CATEGORY chaperone/stress , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    text
  • primarily localized in the endoplasmic reticulum
  • display a restricted distribution and are much less abundant than CACNG2
    • basic FUNCTION
  • part of conserved protein family that acts in the selective transport and maturation of TGFalpha family proteins
  • acting as chaperones for other proteins
  • can affect the trafficking of AMPARS (GRIA1, GRIA2, GRIA3, and GRIN2B), they were not detected on the surface of neurons and failed to alter the kinetics of endogenous AMPARs
  • can modestly enhance the surface expression of AMPARs in neurons, in the absence of CACNG2
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associate with immature TGFalpha family proteins
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS