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FLASH GENE

Symbol

PIGP

contributors: mct - updated : 29-04-2016

HGNC name	phosphatidylinositol glycan, class P
HGNC id	3046

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

EIEE55

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   may lead to or represent impaired glycosylphosphatidylinositol- N-acetylglucosaminyltransferase mediated posttranslational modifications and subsequent anchoring of proteins to the plasma membrane

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

impaired Pigp expression in Kmt2b(-/-) macrophages abolished GPI anchor-dependent loading of proteins on the cell membrane