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FLASH GENE
Symbol PIGP contributors: mct - updated : 29-04-2016
HGNC name phosphatidylinositol glycan, class P
HGNC id 3046
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Dcrc
Homologene
FAMILY
CATEGORY enzyme , transcription factor
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,endoplasmic reticulum
basic FUNCTION
  • regulates convergent extension (CE) movements through the non-canonical Wnt pathway
  • regulates CE in vertebrate embryos by anchoring different Wnt receptors at the cell surface and maintaining Dishevelled stability
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of the GPI-GlcNAc transferase
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • functionally interacted with Knypek/GLI4 and was required for its localization at the cell surface
  • KMT2B is required for the expression of PIGP, the enzyme catalyzing the first step of glycosylphosphatidylinositol (GPI) anchor synthesis
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) EIEE55
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    may lead to or represent impaired glycosylphosphatidylinositol- N-acetylglucosaminyltransferase mediated posttranslational modifications and subsequent anchoring of proteins to the plasma membrane
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • impaired Pigp expression in Kmt2b(-/-) macrophages abolished GPI anchor-dependent loading of proteins on the cell membrane