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FLASH GENE
Symbol NPFFR2 contributors: - updated : 06-09-2007
HGNC name neuropeptide FF receptor 2
HGNC id 4525
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a seven transmembrane segments (7TM) receptor
    • HOMOLOGY
    interspecies homolog to chimpanzee NPFFR2 (98.47 pc)
    homolog to rattus Npffr2 (78.76 pc)
    homolog to murine Npffr2 (79.76 pc)
    homolog to chicken NPFFR2 (67.40 pc)
    intraspecies homolog to neuropeptide y receptor
    Homologene
    FAMILY
  • G protein coupled receptor 1 family
    • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • morphine-modulating peptide playing a role in pain modulation
  • mediating its action by association with G
    • proteins that activate a phosphatidylinositol- calcium second messenger system
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein NPFF receptor
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to leanness, due to increased lipolysis
    Variant & Polymorphism other haplotype ATAG, with allele frequency ~4p100 in Scandinavian cohorts, associated with protection against obesity
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS