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FLASH GENE

Symbol

NPFFR2

contributors: - updated : 06-09-2007

HGNC name	neuropeptide FF receptor 2
HGNC id	4525

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	anonymous DNA segment
STRUCTURE	116.00 kb     5 Exon(s)

motif	Viral sequence   long terminal repeat
text structure	specific HERV-K LTR within intron 1

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 - splicing 1936 variant 1 60.27 522 - Cikos, Ankö lacking exon 2 encoding for the longer product also called GPR74IA variant 2 - splicing 1560 variant 2 48.55 420 only placenta, adipose tissue Cilkos, Ankö lacking exon 1 encoding for the shorter product also called GPR74IB

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain           brain diencephalon amygdala       brain diencephalon hypothalamus     Reproductive female system placenta     highly Skin/Tegument skin       lowly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective       highly Connective bone     moderately

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text	placenta, embryonic tissue

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a seven transmembrane segments (7TM) receptor

HOMOLOGY

interspecies	homolog to chimpanzee NPFFR2 (98.47 pc)
	homolog to rattus Npffr2 (78.76 pc)
	homolog to murine Npffr2 (79.76 pc)
	homolog to chicken NPFFR2 (67.40 pc)

intraspecies

homolog to neuropeptide y receptor

Homologene

FAMILY

G protein coupled receptor 1 family

CATEGORY

receptor

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	morphine-modulating peptide playing a role in pain modulation
	mediating its action by association with G
	proteins that activate a phosphatidylinositol- calcium second messenger system

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein

NPFF receptor

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to leanness, due to increased lipolysis

Variant & Polymorphism other	haplotype ATAG, with allele frequency ~4p100 in Scandinavian cohorts, associated with protection against obesity

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS