Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol XPNPEP1 contributors: mct - updated : 26/09/2008
HGNC name X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
HGNC id 12822
Location 10q25.1      Physical location : 111.624.523 - 111.683.311
Synonym name
  • aminoacylprolyl hydrolase
  • X-prolyl aminopeptidase (aminopeptidase P)-like
  • cytosolic aminopeptidase P
  • Xaa-Pro aminopeptidase 1
  • Synonym symbol(s) XPNPEP, HSAMP, XPNPEPL, SAMP, XPNPEPL1, APP1
    EC.number 3.4.11.9
    DNA
    TYPE functioning gene
    STRUCTURE 58.68 kb     21 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    21 - 2557 - 666 - -
    - - 2485 - 642 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
    Endocrinepancreas   highly
    Nervousbrain    
    Respiratorylung    
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Muscularstriatumskeletal lowly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text pancreas
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a proton shuttle and five divalent metal ligand sites
  • a C terminal hexahistidine tag, catalytic domain coordinating two metal ions and sharing a similar fold with other prolyl aminopeptidases
  • mono polymer dimer
    HOMOLOGY
    interspecies homolog to E.coli methionine aminopeptidase
    Homologene
    FAMILY
  • pita-bread-fold protein family
  • metallopeptidase family M24
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    text cytosolic
    basic FUNCTION
  • catalyze the removal of a penultimate prolyl residue from the N termini of peptides
  • playing a role in the maturation and degradation of peptide hormone, neuropeptide and tachykinin
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor,
  • manganese Mn2+
  • cobalt Co2+
  • protein
  • can degrade bradykinin, a blood pressure-regulating peptide
  • cell & other
    REGULATION
    inhibited by by the specific peptide inhibitor apstatin
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS