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FLASH GENE
Symbol CHERP contributors: mct - updated : 24-04-2013
HGNC name calcium homeostasis endoplasmic reticulum protein
HGNC id 16930
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • G-patch domain
  • glycine-rich nucleic binding domain
  • putative transmembrane domain
  • multiple consensus phosphorylation sites
  • a polyglutamine tract of 12 repeats and regions of imperfect tryptophan and histidine octa and nona -peptide repeats
    • HOMOLOGY
    interspecies ortholog to rattus Cherp_predicted
    ortholog to murine Cherp
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nuclear envelope
    basic FUNCTION
  • playing a role in calcium homeostasis, growth and proliferation
  • involved in negative regulation of cell proliferation
  • involved in regulation of nuclear pre-mRNA protein
  • important component of the ER Ca(2+)-mobilizing system in cells, and its loss impairs Ca(2+)-dependent biochemical pathways and progression through the cell cycle
  • acts as a direct cytoplasmic regulator of IP(3)Rs and RyRs and in the nucleus to impact cellular proliferation by regulating the function of the U2 snRNA spliceosomal complex
    • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS development
    text nervous system development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • CHERP is an RYR1 interacting protein that may be involved in the regulation of excitation-contraction coupling
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS