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FLASH GENE
Symbol FOXJ2 contributors: - updated : 09-03-2005
HGNC name forkhead box J2
HGNC id 24818
RNA
TRANSCRIPTS type messenger
text two isoforms FHX-L and FHX-S
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 4870 62 574 - Perez-Sanchez
more potent transactivator than FOXJ2S
- - 2680 57 526 - Perez-Sanchez
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Lymphoid/Immunethymus    
Reproductivefemale systemovary   
 female systembreastmammary gland  
Respiratorylung    
Urinarykidney    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text early onset in preimplantation development
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a transactivation domain of the acidic type,onsly present in FHX-L
  • two tyrosine residues and a stretch of basic amino acid residues at the N and C-terminal ends of the fork head domain, important for its nuclear targeting
  • two other transactivation domains: domain I, at the N terminus, and the H/P domain, rich in histidine and proline residues
  • HOMOLOGY
    Homologene
    FAMILY forkhead family of transcriptional factors
    CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION transcriptional activator. able to bind to two different type of DNA binding sites
    CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS