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FLASH GENE

Symbol

FOXJ2

contributors: - updated : 09-03-2005

HGNC name	forkhead box J2
HGNC id	24818

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	12pter-p13.31      Physical location : 8.185.358 - 8.208.117
Genatlas name	fork-head transcriptional activator
Synonym symbol(s)	FHX

DNA

TYPE	functioning gene
STRUCTURE	22.00 kb     11 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

text	two isoforms FHX-L and FHX-S

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed isoform L - - 4870 62 574 - Perez-Sanchez more potent transactivator than FOXJ2S isoform S - - 2680 57 526 - Perez-Sanchez

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Lymphoid/Immune thymus         Reproductive female system ovary         female system breast mammary gland     Respiratory lung         Urinary kidney

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text	early onset in preimplantation development

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a transactivation domain of the acidic type,onsly present in FHX-L
	two tyrosine residues and a stretch of basic amino acid residues at the N and C-terminal ends of the fork head domain, important for its nuclear targeting
	two other transactivation domains: domain I, at the N terminus, and the H/P domain, rich in histidine and proline residues

HOMOLOGY

Homologene

FAMILY

forkhead family of transcriptional factors

CATEGORY

regulatory , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION

transcriptional activator. able to bind to two different type of DNA binding sites

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS