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FLASH GENE

Symbol

ARPC1B

contributors: - updated : 12-04-2007

HGNC name	actin related protein 2/3 complex, subunit 1B, 41kDa
HGNC id	704

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	ubiquitous

constitutive of

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon   moderately   salivary gland       highly   stomach       moderately Endocrine pancreas       moderately Lymphoid/Immune tonsils       highly Nervous nerve cranial nerve     moderately Reproductive female system placenta     moderately   female system breast mammary gland   moderately   female system uterus cervix   moderately Respiratory lung       moderately Skin/Tegument skin       moderately Visual eye       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     moderately Connective       moderately Connective adipose     moderately

cells

System Cell Pubmed Species Stage Rna symbol   digestive

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text	embryonic tissue at a lowly level

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

six WD repeat

mono polymer

homomer , heteromer , complex

HOMOLOGY

interspecies	homolog to yeast S.pombe Sop2-like
	homolog to chimpanzee ARPC1B (99,45 pc)
	homolog to rattus Arpc1b (96,77 pc)
	homolog to murine Arpc1b (97,04 pc)
	homolog to chicken ARPC1B (91,16 pc)

Homologene

FAMILY	SOP2 family
	WD repeat ARPC1 family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton
text	localized to the lamellipoda of stationary and locomoting

basic FUNCTION	structural constituent of cytoskeleton
	involved in the actin polymerization cell control
	involved in gastric cancer development progression
	used as a prediction marker gene for sensitivity of Choroidal Malignant Melanomas (CMM) to radiotherapy

CELLULAR PROCESS	cell life, proliferation/growth
	cell organization/biogenesis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

subunit 1B constituent of actin related protein 2/3 complex

INTERACTION

DNA

RNA

small molecule

protein

actin

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS