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FLASH GENE
Symbol GPR27 contributors: mct - updated : 12-04-2014
HGNC name G protein-coupled receptor 27
HGNC id 4482
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane domains
  • potential N linked glysosylation sites in the N extracellular domain
  • conserved cysteine residues forming disulfide bridge in the first and second extracellular loops
    • HOMOLOGY
    interspecies homolog to rattus Sreb1
    Homologene
    FAMILY
  • rhodopsin family
    • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • is a positive regulator of insulin production
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PDX1 is important for GPR27 effect on the insulin promoter and insulin secretion
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS