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FLASH GENE
Symbol SLC46A2 contributors: mct - updated : 16-07-2008
HGNC name SLC46A2 solute carrier family 46, member 2
HGNC id 16055
Location 9q32      Physical location : 115.641.200 - 115.653.193
Synonym name
  • thymic stromal co-transporter
  • thymic stromal cotransporter homolog
    • Synonym symbol(s) TSCOT, Ly110
    DNA
    TYPE functioning gene
    STRUCTURE 11.00 kb     4 Exon(s)
    regulatory sequence Binding site   HRE
    text structure binding site for an interferon alpha inducible factor
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 2445 51.1 475 - Engelmark (2008)
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticthymus   highly
    Urinarykidney   lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • twelve transmembrane region
  • small segment of the central cytoplasmic loop
    • HOMOLOGY
    Homologene
    FAMILY
  • major facilitator superfamily
  • SLC46A family
    • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • having a role in both thymal development and the peripheral function of T-cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to cervical cancer with with high mean age at diagnosis
    Variant & Polymorphism SNP increasing the risk of cervical cancer with with high mean age at diagnosis
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS