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FLASH GENE
Symbol STC2 contributors: mct - updated : 29-06-2016
HGNC name stanniocalcin 2
HGNC id 11374
DNA
TYPE functioning gene
STRUCTURE 14.78 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
Binding site   HRE
text structure
  • promoter contains multiple putative xenobiotic response elements clustered in a 250-bp region that was shown to recruit the AHR by chromatin immunoprecipitation.
    • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 5361 - 302 - 2000 10947959
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart     Homo sapiens
    Endocrinepancreas     Homo sapiens
    Lymphoid/Immunespleen     Homo sapiens
    Reproductivefemale systemuteruscervix highly
     female systembreastmammary gland  
    Urinarykidney     Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal signal peptide
  • a cysteine-rich region
  • 10 conserved cysteine residues with STC1
  • AAs 181–200 of STC2 constitute the essential binding motif for HMOX1
  • cluster of histidine residues in the C terminus
    • conjugated GlycoP
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine Stc2
    intraspecies paralog to STC1
    Homologene
    FAMILY potential member of the heat shock protein family
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus
    basic FUNCTION
  • may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis
  • promotes epithelial-mesenchymal transition and invasiveness in hypoxic human ovarian cancer cells
  • functional homodimeric glycoprotein, and thecal cell-derived STC2 could play a paracrine role during follicular development
  • dual role for STC2 in neuroblastoma, reduces proliferation of tumor cells in vitro, but increases the invasive potential and induces bleeding, and thereby may facilitate early metastasis
    • and is a positive regulator in tumor progression at hypoxia
  • involvement of STC2 in responding to pancreatic acinar cell injury
  • prosurvival component of the unfolded protein response
  • cell-intrinsic role for STC2 in the regulation of store-operated Ca(2+) entry (SOCE), and modulation of SOCE through STC2 expression is one of the prosurvival measures of the unfolded protein response
  • functions likely as a stress protein
  • is a novel receptor target gene previously reported to have a cytoprotective role in endoplasmic reticulum stress
  • STC1, STC2 are known to be involved in tumor progression and metastasis
  • STC1 and STC2 play positive roles in angiogenic sprouting
  • is a novel proteinase inhibitor and a previously unrecognized extracellular component of the IGF system
  • STC2 can be used to enhance cell survival and maintain long-term stemness in therapeutic use of stem cells
  • CPNE1 and STC2, were confirmed to be modifiers of in vitro myogenesis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    a component
  • HMOX1-STC2 complex may represent a eukaryotic ‘stressosome’ in conditions where heme is liberated
    • INTERACTION
    DNA
    RNA
    small molecule metal binding,
    metal ions
    protein
  • caseine kinase 2
  • HMOX1 is a binding partner of STC2
  • STC2 binds hemin via a consensus heme regulatory motif
  • potently inhibits the proteolytic activity of the growth-promoting metalloproteinase, pregnancy-associated plasma protein-A (PAPPA)
  • presence of native complexes between PAPPA and STC1, STC2 in the human ovary, indicating STC-mediated PAPPA proteolytic inhibition
    • cell & other
    REGULATION
    activated by EIF2AK3, (PKR)-like Endoplasmic Reticulum Kinase (PERK) signalling, under conditions of ER stress in vitro
    induced by can be induced by heat shock
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS