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FLASH GENE

Symbol

PEX14

contributors: mct/npt - updated : 01-02-2015

HGNC name	peroxisomal biogenesis factor 14
HGNC id	8856

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES		acid		Hydrophobic
STRUCTURE

motifs/domains	N-terminal domain mediating molecular interactions with PEX5 and PEX19, and modulating peroxisomal targeting of PEX14
	an aspartic-acid and glutamic acid rich region
	a non-membrane hydrophobic region
	a coiled-coil region
	a charged acidic C terminus
	a single putative transmembrane domain
	C-terminal two-thirds are exposed into the cytosol, whereas its N-terminal domain is either embedded in the peroxisomal membrane or even exposed into the matrix of the organelle

mono polymer

heteromer , dimer

HOMOLOGY

interspecies	ortholog to rattus Pex14
	ortholog to murine Pex14

Homologene

FAMILY

peroxin 14 family

CATEGORY

regulatory , storage

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,peroxisome
text	intrinsic peroxisomal membrane protein
	outer face

basic FUNCTION	involved in the transcription regulation of specific erythroid and megakaryocytic gene
	putative docking protein for PEX5, the peroxisomal cycling receptor
	multi-tasking protein that not only facilitates peroxisomal protein import but is also required for peroxisome motility by serving as membrane anchor for microtubules
	role of PEX14 in the release of cargo proteins into the peroxisomal matrix
	essential import receptors PEX3 and PEX14 target mitochondria, where they are selectively released into vesicular pre-peroxisomal structures

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

component of the peroxisomal translocation machinery with PEX13 and PEX17

INTERACTION

DNA

RNA

small molecule

protein	PEX13 (SH3 protein domain), putative docking protein for PTS1-dependent protein import, with HDAC1
	central component of the peroxisomal import machinery and binds the soluble receptors PEX5 and PEX19
	tubulin was discovered to be the major PEX14-associated protein
	N-terminal region in PEX26 acts as a scaffold protein to recruit PEX14·PEX5 complex together with PEX1·PEX6 complexes on peroxisomes
	in the peroxisomal protein import, AAA peroxins modulate the interaction between PEX26 and PEX14 on peroxisome membrane as well as PEX5 oligomer in the cytosol

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

PBD10

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in favorable subset of primary neuroblastoma tumoral     --low   in unfavorable subset of primary neuroblastoma

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS