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FLASH GENE
Symbol ACSS2 contributors: - updated : 02-12-2005
HGNC name acyl-CoA synthetase short-chain family member 2
HGNC id 15814
Location 20q11.2-q12      Physical location : 33.462.765 - 33.515.769
Synonym name
  • acetate-CoA ligase
  • acetyl-Coenzyme A synthetase 2 (ADP forming)
  • Synonym symbol(s) ACS, ACECS2, ACAS2, MYH7B
    EC.number 6.2.1.13
    DNA
    TYPE functioning gene
    STRUCTURE 51.00 kb     18 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 2920 78 701 - Luong
    - splicing 2770 - 606 - Luong
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveliver   lowly
    Endocrinepancreas   lowly
    Nervousbrain   lowly
    Reproductivemale systemprostate  lowly
    Respiratorylung   lowly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer monomer
    HOMOLOGY
    interspecies homolog to yeast Acs
    Homologene
    FAMILY ATP-dependant AMP-binding enzyme family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • oxydation of acetate
  • activate acetate for lipid synthesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by SREBP (sterol regulatory element binding protein)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS