Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Orphanet	Ensembl
	HGNC	UniGene	Nucleotide	OMIM		UCSC

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FLASH GENE

Symbol

HAX1

contributors: mct/pgu - updated : 23-12-2020

HGNC name	HCLS1 associated protein X-1
HGNC id	16915

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

SCNP3

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in lesional psoriatic skin constitutional     --over   protects cardiac myocytes from apoptosis through caspase-9 inhibition constitutional     --over   reduced sarcoplasmic reticulum Ca-ATPase (SERCA2) pump activity in isolated cardiomyocytes and leading to depressed myocyte calcium kinetics and mechanics tumoral     --over   in hepatocellular carcinoma (HCC)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	HAX1 can be a novel molecular marker for HCC
	HAX1 could be considered as a potential biomarker of cardiac disease in FRDA
Therapy target
	System Type Disorder Pubmed cancer     is a potential therapeutic target for the treatment of cancer cancer digestive liver could be a potential therapeutic target for HCC treatment

ANIMAL & CELL MODELS

murine Hax1(-/-) B cells show a significantly reduced expression of CXCR4, which might have an influence on the observed defects in B-cell development