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FLASH GENE

Symbol

HIC1

contributors: mct - updated : 24-05-2014

HGNC name	hypermethylated in cancer 1
HGNC id	4909

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional   deletion     in Miller-Dieker syndrome tumoral     --low   in medulloblastoma by altered CpG island methylation tumoral   LOH   loss of function by hypermethylation, in breast ductal carcinomas tumoral     --low   by hypermethylation and hypermethylation of its promoter results in loss of its repressive function, responsible for prostate cancer progression and invasion

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	HIC1-LCN2 axis may serve as a subtype-specific prognostic biomarker in triple-negative breast cancer
Therapy target

ANIMAL & CELL MODELS

putatively involved in the pathogenesis as suggested by the developmental defects observed in Hic1 deficient mice